|
KMID : 0391519970050010180
|
|
Journal of the Korean Child Neurology Society
1997 Volume.5 No. 1 p.180 ~ p.180
|
|
|
Epilepsy in Children and Vigabatrin : Experiences in the USA
|
|
W. Donald Shields
|
|
|
Abstract
|
|
|
-Abstract-
Many children with epilepsy remain medically intractable inspire of the best available
therapies. One of the most difficult seizure types to treat is infantile spasms. Many
children will respond to treatment with ACTH but there are may serious side effects
and many children relapse when the medication is reduced or discontinued. Thus, new
therapies are critically needed for this group of patients. Early evidence from European
trials indicated that vigabatrin (Sabril) was effective in this population.
A randomized, single blind, high-dose vs low dose vigabatrin study was performed in
a multicenter USA trial. Between January 1996 and May 1997, 89 patients from 7
pediatric epilepsy centers were started in the study. An interim evaluation was
performed on September 14, 1997. Of the 89 patients, data was not yet available for 16
so 73 patients were evaluable for safety. Efficacy was evaluated in 63 of the patients.
Two were eliminated because they had violated the entry criteria and 8 did not yet
report the efficacy information and had to be excluded from the interim report.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|